Fig. 4. Effect of treatment with LINS01005 and LINS01007 on cytokines and chemokines production. Lungs were collected 24h after the second challenge to quantify the cytokines and chemokines production. Lung tissue was processed and IL-5 (A), IL-6 (B), IL-13 (C), TNF-α (D), IFN-γ (E), and RANTES (F) production were measured by multiplex assays as described in Material and Methods. Results are the mean ± S.E.M. of 5 animals in each of 3 independent experiments. *p<0.05 and **p<0.01 and in comparison with the control group and #p<0.05 and ##p<0.01 in comparison with the asthma group.